Consequences of Low Glutathione Level

What happens when cells have low level of glutathione or increased level of oxidized glutathione?

Lowered GSH

• Functional Cobalamin deficiency (vitamin B12) / Ref. 1-2
• Functional Copper deficiency / Ref. 3
• Functional Zinc deficiency / Ref. 4
• Cysteine deficiency / Ref. 5
• inefficient Iron-Sulfur clusters assembly (impairs energy production) / Ref. 6-7
• Inactivation of TPH2 enzyme (in the brain), which leads to reduced Serotonin synthesis (R8)
• Functional Vitamin D deficiency / (R9, R10)

All this can happen despite the normal or high levels of mentioned nutrients in the blood. That’s why these deficiencies are called functional here.

The mind map below describes the consequences of intracellular GSH depletion.

Elevated GSSG (oxidized GSH)

• Reduced synthesis of Creatine (R11)

Mind Map

This is a mind map compiled from various scientific studies and reviews. You can see quotes from original texts, pictures and links to the studies. Open the map.