My Posts

Activation of WNT3A prevents deactivation of Nrf2 by GSK3b
August 25, 2024
#WNT3A #Nrf2 #GKS3b #Axin1
PDE10A inhibition as a possible treatment of TS
July 26, 2024
#PDE10A #cAMP #cGMP #Phosphodiesterases #Tourette Syndrome #Basal ganglia
Reduction of OCD by intracellular acidification of cortical neurons
July 25, 2024
#OCD #Proton Pump Inhibitor #Quinpirole #D2R
TRP14 reduces cystine and PTP1B
July 10, 2024
#TRP14 #TXNDC17 #Cystine #Cysteine #TXNRD1 #PTP1B
MAPK, p62, autophagy and inflammation
June 18, 2024
#MAPK #SQSTM1 #p62 #Autophagy #GABA-A Receptor #ULK1 #Inflammation #NRF2
Beta-catenin downregulates p62
June 3, 2024
#beta-catenin #Wnt #GSK3b
Higher Nrf2 activation may be needed for activating metabolic genes vs. cytoprotective genes
June 3, 2024
#Nrf2 #PI3K #Akt #PTEN #KEAP1
Batten Disease
May 25, 2024
#Batten disease #Lysosome
Palmitoylation of Gephyrin
May 25, 2024
#Gephyrin #Palmitoylation #ZDHHC12 #Claudin-3 #NLRP3 #ZDHHC13 #ZDHHC21
Folate deficiency leads to increased autophagosome markers
May 14, 2024
#Folate #Autophagy #Beclin-1 #mTOR #mTORC2 #mTORC1 #Akt
Citicoline affects proteosome in a dose-dependent manner
May 11, 2024
#Citicoline #Proteasome #Epoxomicin
Streptolysin S inhibits GSK3b degradation, damages mitochondria
May 9, 2024
#Streptolysin S #Streptococcus #GSK3b #Oxidative stress #Proteasome
Possible link between Proteolysis, melatonin production and Tourette's syndrome
May 9, 2024
#Proteolysis #Melatonin #Propranolol #GABA #Hypertension #AANAT #cAMP
Muscarinic receptors, tics and GSK3b
May 4, 2024
#Muscarinic Receptors #M4R #GSK3b #Tourette Syndrome #Xanomeline #Pilocarpine
Nrf2 activation leads to imbalance of carbon metabolism
May 3, 2024
#NRF2 #Glutamine #Glutamate #GSH #KEAP1 #xCT
Oxidative stress lowers testosterone production
April 27, 2024
#SIRT1 #NRF2 #Testosterone #Progesterone #NAM #Niacinamide #Oxidative stress #Hypogonadism #Luteinizing hormone
Amoxicillin decreased KEAP1, CPT1, CHOP expression and PPARa transactivation
April 20, 2024
#Amoxicillin #NRF2 #KEAP1 #CPT1 #CHOP #PPARa #Carnitine #Tics
Magnesium stimulates eflux of cystine from lysosomes
April 19, 2024
#Cystine #Lysosomes #Magnesium #ATPase
Iron Supplementation on Attention Deficit Hyperactivity Disorder in Children
April 15, 2024
#Iron #ADHD
DRAM1 is a novel susceptibility locus identified in TS
April 13, 2024
#Tourette Syndrome #Autophagy #Lysosome #DRAM1
Progesterone inhibits GSK3b
March 25, 2024
#Progesterone #GSK3b #Nrf2 #Akt #Chromium #Vanadium #Menstrual Cycle
Autophagy, inositol, lithium and Prolyl Oligopeptidase
February 25, 2024
Genetic overactivation of Nrf2: consequences and treatment
February 11, 2024
#Nrf2 #NFE2L2 #Luteolin #Ascorbic acid #Immunodeficiency #Hyperkeratosis #Hypohomocysteinaemia #G6PD
Iron deficiency may lead to impaired PPI
February 11, 2024
#Iron #Iron Deficiency #PPI #Prepulse Inhibition #Schizophrenia
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
February 4, 2024
#Chloroquine #Autophagy #Lysosome
PI3K/Akt regulates CoA synthesis
February 4, 2024
#Coenzyme A #PI3K #AKT #PANK2 #PANK4 #Chromium #Vanadium
Guanfacine stabilizes lysosomes in high oxidative stress
January 28, 2024
L-Theanine and tics
January 27, 2024
#Theanine #Tics #Hyperactive bladder #Inflammation #PKC #ERK #p38 #NF-bB #ICAM-1 #IL-33 #Oxidative stress #Autophagy
DHA inhibits proteolysis
January 25, 2024
#Tics #DHA #Lysosome #Proteasome #Ubiquitin #Autophagy
Dual role of Biotin in regulating Autophagy
January 20, 2024
#Biotin #Autophagy #mTORC1
Cytokine Expression in Tic Disorders
January 4, 2024
#Cytokine #IL1b #TNF-a #IL6 #IL4 #IL17
Copper is a cofactor of SUMF1
December 8, 2023
#Copper #SUMF1 #Lysosome #Lysosomal Storage Disorder #Multiple Sulfatase Deficiency #Sulfatases
Role of MAFF in dampening Nrf2 signal
October 22, 2023
#Nrf2 #MAFF #Hypoxia #HIF1 #IL1b #TNFa #Cytokines
Calcium paradox: deficiency causes overload
October 3, 2023
#Calcium #Hypertension
Aripiprazole
October 3, 2023
#Aripiprazole #OCD #ADHD #Tics #Weight gain #Akathisia #D2 Receptor
Role of excessive ubiquitination in BH4 deficiency
September 22, 2023
#BH4 #Tetrahydrobiopterin #GTPCH1 #Ubiquitination #p62 #Hypertension #Diabetes Mellitus 2 #Autophagy #Lysosome
Energy deprivation inhibits Akt
September 3, 2023
#Akt #AMPK #Energy #PI3K #IRS-1
Induction of deficiencies by thiamine
September 2, 2023
#Thiamine #Elliot Overton #Riboflavin #Niacin #DAAO #Risperidone
GSK3b inactivates PDHC
August 30, 2023
#GSK3b #PDHC #Thiamine #Acetylcholine
Klazomania - compulsive, paroxysmal, loud shouting
August 26, 2023
Beta-Mannosidase Deficiency and TS
August 22, 2023
#Tourette Syndrome #Beta-mannosidase deficiency #MANBA #Lysosome #Mental retardation #Hearing loos #Behavior #Infections #Mannose #N-acetylglucosamine #NAG
Macrocytosis (folate/B12 deficiencies) and microcytosis (iron deficiency)
August 12, 2023
#Macrocytosis #Microcytosis #MCV #MCH #Folate #B12
Activation of the inflammasome NLRP3 by oxidative stress
July 31, 2023
#Inflammasome #NLRP3 #Oxidative stress #GSH #H2S
BTBD9 gene and TS
July 24, 2023
#BTBD9 #CRL3 #Tourette syndrome #Iron #Autophagy #MEIS1 #MAP2K5 #SKOR1 #RLS #IRP2
Traumatic Brain Injury impairs degradation of autophagosomes
July 21, 2023
#TBI #Autophagy
Pimozide promotes autophagy, used to lower tics
July 20, 2023
#Pimozide #Autophagy #UPR #Tourette syndrome #Schizophrenia #Psychosis
Reduced autophagy leads to reduction of GABA-A receptors
July 18, 2023
#Autophagy #GABA-A #p62 #SQSTM1
Inhibited autophagy blocks xCT transport to the membrane
July 18, 2023
#Autophagy #Nrf2 #xCT #SLC7A11 #Cystine
Biotin deficiency and high cholesterol
July 8, 2023
#biotin #cholesterol
Role of Allopregnanolone in tics severity
July 5, 2023
#Allopregnanolone #Tics #Tourette syndrome #GABA #Interneurons