My Posts

Deregulated Nrf2-Keap1-BACH1 axis in autism spectrum disorder
NRF2 BACH1 Autism ASD Tics p62 Heme Iron
OCD and Impulsivity in Late-Onset Isolated Sulfite Oxidase Deficiency
SUOX OCD Molybdenum Aggression
Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats
Apple's content activate Nrf2
Apple Nrf2
Interactions of Coenzyme Q10 and PI3K-Akt pathway
CQ10 Akt PI3K Autophagy mTOR
Reduced Folate Carrier 1 can export thiamine pyrophosphate
Folate Thiamine RFC1 SLC19A1 SLC46A1
UTP is required for vitamin B1 utilization
Thiamine TPP UTP Pyrimidines TPK1
Metabolic Dangers of Nrf2 activation
Nrf2 KEAP1 NAD ALDH3A1 Reductive Stress
TXNRD1 reactivates oxidized PTP1B
PTP1B TXNRD1 PDGF-beta receptor
L-selenocystine is toxic for Nrf2 addicted cells
Nrf2 Selenocystine Autophagy p62 KEAP1 Oxidative Stress AKT mTOR ULK1 Beclin1
Clerodendrum inerme stopped tics
Proteasome Tics Clerodendrum inerme Gaertn Glory Bower Betulinic acid
Activation of WNT3A prevents deactivation of Nrf2 by GSK3b
WNT3A Nrf2 GKS3b Axin1
PDE10A inhibition as a possible treatment of TS
PDE10A cAMP cGMP Phosphodiesterases Tourette Syndrome Basal ganglia
Reduction of OCD by intracellular acidification of cortical neurons
OCD Proton Pump Inhibitor Quinpirole D2R
TRP14 reduces cystine and PTP1B
TRP14 TXNDC17 Cystine Cysteine TXNRD1 PTP1B
MAPK, p62, autophagy and inflammation
MAPK SQSTM1 p62 Autophagy GABA-A Receptor ULK1 Inflammation NRF2
Beta-catenin downregulates p62
beta-catenin Wnt GSK3b
Higher Nrf2 activation may be needed for activating metabolic genes vs. cytoprotective genes
Nrf2 PI3K Akt PTEN KEAP1
Batten Disease
Batten disease Lysosome
Palmitoylation of Gephyrin
Gephyrin Palmitoylation ZDHHC12 Claudin-3 NLRP3 ZDHHC13 ZDHHC19 SQSTM1 p62 ZDHHC21
Folate deficiency leads to increased autophagosome markers
Folate Autophagy Beclin-1 mTOR mTORC2 mTORC1 Akt
Citicoline affects proteosome in a dose-dependent manner
Citicoline Proteasome Epoxomicin
Streptolysin S inhibits GSK3b degradation, damages mitochondria
Streptolysin S Streptococcus GSK3b Oxidative stress Proteasome
Possible link between Proteolysis, melatonin production and Tourette's syndrome
Proteolysis Melatonin Propranolol GABA Hypertension AANAT cAMP
Muscarinic receptors, tics and GSK3b
Muscarinic Receptors M4R GSK3b Tourette Syndrome Xanomeline Pilocarpine
Nrf2 activation leads to imbalance of carbon metabolism
NRF2 Glutamine Glutamate GSH KEAP1 xCT
Oxidative stress lowers testosterone production
SIRT1 NRF2 Testosterone Progesterone NAM Niacinamide Oxidative stress Hypogonadism Luteinizing hormone
Amoxicillin decreased KEAP1, CPT1, CHOP expression and PPARa transactivation
Amoxicillin NRF2 KEAP1 CPT1 CHOP PPARa Carnitine Tics
Magnesium stimulates eflux of cystine from lysosomes
Cystine Lysosomes Magnesium ATPase
Iron Supplementation on Attention Deficit Hyperactivity Disorder in Children
Iron ADHD
DRAM1 is a novel susceptibility locus identified in TS
Tourette Syndrome Autophagy Lysosome DRAM1
Progesterone inhibits GSK3b
Progesterone GSK3b Nrf2 Akt Chromium Vanadium Menstrual Cycle
Autophagy, inositol, lithium and Prolyl Oligopeptidase
Genetic overactivation of Nrf2: consequences and treatment
Nrf2 NFE2L2 Luteolin Ascorbic acid Immunodeficiency Hyperkeratosis Hypohomocysteinaemia G6PD
Iron deficiency may lead to impaired PPI
Iron Iron Deficiency PPI Prepulse Inhibition Schizophrenia
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Chloroquine Autophagy Lysosome
PI3K/Akt regulates CoA synthesis
Coenzyme A PI3K AKT PANK2 PANK4 Chromium Vanadium
Guanfacine stabilizes lysosomes in high oxidative stress
L-Theanine and tics
Theanine Tics Hyperactive bladder Inflammation PKC ERK p38 NF-bB ICAM-1 IL-33 Oxidative stress Autophagy
DHA inhibits proteolysis
Tics DHA Lysosome Proteasome Ubiquitin Autophagy
Dual role of Biotin in regulating Autophagy
Biotin Autophagy mTORC1
Cytokine Expression in Tic Disorders
Cytokine IL1b TNF-a IL6 IL4 IL17
Copper is a cofactor of SUMF1
Copper SUMF1 Lysosome Lysosomal Storage Disorder Multiple Sulfatase Deficiency Sulfatases
Role of MAFF in dampening Nrf2 signal
Nrf2 MAFF Hypoxia HIF1 IL1b TNFa Cytokines
Calcium paradox: deficiency causes overload
Calcium Hypertension
Aripiprazole
Aripiprazole OCD ADHD Tics Weight gain Akathisia D2 Receptor
Role of excessive ubiquitination in BH4 deficiency
BH4 Tetrahydrobiopterin GTPCH1 Ubiquitination p62 Hypertension Diabetes Mellitus 2 Autophagy Lysosome
Energy deprivation inhibits Akt
Akt AMPK Energy PI3K IRS-1
Induction of deficiencies by thiamine
Thiamine Elliot Overton Riboflavin Niacin DAAO Risperidone
GSK3b inactivates PDHC
GSK3b PDHC Thiamine Acetylcholine