High serotonin & anxiety

Counterintuitive perspective, really.

“However, how the positive modulation of serotonin tone translates into raised mood or decreased anxiety is not yet understood and the precise relationship between certain behaviors and brain serotonin levels remains unclear.

For instance, anxiolysis as a result of reducing brain serotonin is well established, suggesting that serotonin increases anxiety.

However, anxiety is often paired with depression, which is classically associated with low serotonin levels (Jennings et al., 2010). Also, SSRIs are effective in treating both disorders, but only in a fraction of patients.”