Lanthionine

CSE in the brain

However, recent studies have demonstrated that CSE is both present and active in the brain (17, 18) and that H2S is in fact detected in the brains of transgenic mice lacking CBS (19). The major role of CSE in H2S biogenesis in the peripheral system has been convincingly demonstrated in CSE knock-out mice, which exhibit significantly reduced H2S levels in the serum and lower H2S production rates in aorta and heart (20). The CSE knock-out mice exhibit hypertension and reduced endothelium-dependent vasorelaxation. (R3)