Mitochondrial oxidative stress: blood-brain barrier disruption

Highlights

• Blood-brain barrier plays a central role in a variety of central nervous system diseases and is a drug target.

• Mitochondrial oxidative stress disorder in brain microvascular endothelial cells plays a key role in the occurrence and development of blood–brain barrier damage.

• Protection of mitochondrial function in brain microvascular endothelial cells is a potential new strategy for the treatment of central nervous system diseases.