Research Notes by Sergey
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June 19, 2022
  • #NNMT
  • #Methylation
  • #BHMT
  • #AHCY
  • #MAT1A

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References

NNMT regulates methyl donor metabolism

It’s a common knowledge that excess of NAM gets methylated and many people think that Niacin or Nicotinamide (NAM) will lower methylation potential by spending SAMe. There is even a concept of methyl sink assigned to Niacin.

The article below suggests that NNMT, the enzyme that methylates NAM, may have a second role - interaction with enzymes of the methionine cycle. Specifically it seems to interact with BHMT, AHCY and MAT1A.

References

1
NicotinamideĀ N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism
2018
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