Oxidative stress in Tourette's syndrome

How did that paper escaped my attention before?!?!

This is what I’ve been saying for several years.

Children with Tourette’s syndrome have high levels of biochemical indices of oxidative stress and the quantitative immunoglobulins.

These findings add to the still-limited knowledge on the pathogenesis of Tourette’s syndrome and may have implications for the development of novel therapeutic modalities.

Another findings from the paper are surprising, but can be explained though:

Compared with the control group, the Tourette’s syndrome group had significantly higher levels of ferritin (p = 0.01) and hemoglobin (p = 0.02), a lower level of zinc (p = 0.05), and a lower percentage of non-ceruloplasmin copper (p = 0.01).

High ferritin can be explained by increased activation of Nrf2 pathway (due to high oxidative stress), which increases expression of ferritin to lock iron in the safe cage. That results in iron being unavailable for the cells until Nrf2 calms down (however this doesn’t explain higher hemoglobin).