Autophagy, inositol, lithium and Prolyl Oligopeptidase
While reading a great review about the role of neuronal autophagy - “Autophagy in neuronal physiology and disease” (R1), I stumbled upon this claim:
Mood stabilizers (i.e. lithium, valproate, carbamazepine) commonly induce autophagy via inhibiting the inositol monophosphatase pathway (R1)
Which refers to another paper – “A common mechanism of action for three mood-stabilizing drugs” (R2).
That paper concerns whether the effect of valproic acid and lithium can be explained by inhibition of GSK3b or depletion of inositol. The conclusion was that these chemicals are likely to activate the enzyme Prolyl Oligopeptidase, which in turn regulates inositol metabolism.