H2S clearance and reversal of ETC, role of CQ10

Elliot’s post about Hydrogen Sulfide and CQ10 encouraged me to dig deeper because this topic feels very relevant to our case.

First, I found that high levels of H2S inhibits Complex IV and reverses Complex II in order to detox H2S. (R1)

While H2S oxidizing enzyme does need CQ10 to clear H2S, the level of CQ10 is important - less CQ10 seems to help clear H2S faster (R1).

I suspect that inability to detox H2S fast enough is implicated in specific neuropsychiatric symptoms in our case.

E.g. H2S leads to impaired pre-pulse inhibition (PPI) - something that we see daily in the form spontaneous anxiety attacks and startling from sounds. I have an article about this topic (R2).

Excessive H2S also inhibits various energy-related enzymes by sulfhydrating them. For example, excessive H2S inhibits Akt, which leads to lowered sensitivity to insulin and impaired Nrf2 activation.

Digging deeper, it seems ETC dysfunction y is related to autism and schizophrenia too (R3).

My conclusion: to pay more attention to H2S topic. It’s not as simple as “take molybdenum”.