Iron deficiency may lead to impaired PPI

Found a paper that shows Prepulse Inhibition is impaired as a result of Iron Deficiency.

Why it’s relevant to this group: some tics are triggered by own thoughts or external stimuli and I believe this type of tics is related to impaired prepulse inhibition (PPI).

PPI also impaired in OCD according to other studies.

These results, in combination with previous findings demonstrating impaired hippocampus functioning and altered dopaminergic and glutamatergic neurotransmission, suggest that** iron availability within the hippocampus is critical for the neurodevelopmental processes underlying sensorimotor gating**.

Ultimately, evidence of reduced PPI in both of our models may offer insights into the roles of fetal ID and the hippocampus in the pathophysiology of schizophrenia.