Altered phospholipid and creatine in OCD

A new area of research for me - lipid composition of cellular membranes and how it’s relevant to diseases, specifically to OCD.

There is some body of research already done, e.g.:

Results:

Significantly, increased concentrations of PC, PDE, PME, GPC, PME/PCr, PDE/PCr were found in patients compared to controls in the striatum and the thalamus. PCr and tATP were decreased in the striatum. Finally, significant correlations were found in the striatum and the thalamus between illness duration and some specific measured parameters.

Conclusion:

Our results showed significant modifications of the membrane and energy metabolism in the basal ganglia of severe OCD patients and suggests a link between energetic buffer and serotonin metabolism disorder."

Reference

1. Altered phospholipid and high-energy phosphate metabolism in the basal ganglia and thalamus of severe obsessive compulsive patients with treatment resistance: A phosphorus 31 nuclear magnetic resonance spectroscopy study, 2021 / Pubmed