DAG and antidepressants

It seems that disturbance in synthesis of CDP-diacylglycerol in the cells has direct effect on psychiatric symptoms.

For example, specific antidepressants stimulate synthesis of CDP-DAG and have the desired effect even without changing reuptake of serotonin.

Recent studies demonstrate that diverse antidepressant agents increase the cellular production of the nucleolipid CDP-diacylglycerol and its synthetic derivative, phosphatidylinositol, in depression-relevant brain regions. Pharmacological blockade of downstream phosphatidylinositide signaling disrupted the behavioral antidepressant effects in rats. However, the nucleolipid responses were resistant to inhibition by serotonin receptor antagonists, even though antidepressant-facilitated inositol phosphate accumulation was blocked.

I have a strong feeling that it’s the DAG (diacylglycerol) and signalling cascade downstream of it are the key to treat OCD.