Chromium inhibits ATP synthase directly

A recently published paper, shows that Chromium targets ATP synthase directly. Which makes Cr a mito nutrient now.

Except that, the direct effect of Cr is decrease of ATP synthesis, which triggers AMPK activation (a good thing).

We show that Cr(III) binds to ATP synthase at its beta subunit via the catalytic residues of Thr213/Glu242 and the nucleotide in the active site.

Such a binding suppresses ATP synthase activity, leading to the activation of AMPK, improving glucose metabolism, and rescuing mitochondria from hyperglycaemia-induced fragmentation. (R1)

If you thought you need unlimited amount of ATP, think again.