PI3K/Akt regulates CoA synthesis

How interesting - synthesis of CoA from B5 is regulated by PI3K/Akt pathway.

And that means that poor status of chromium (and vanadium) will lower synthesis of CoA because they are essential for amplification of PI3k/Akt pathway.

We identify pantothenate kinase 2 (PANK2) and PANK4 as substrates of the PI3K effector kinase AKT.

Although PANK2 is known to catalyse the rate-determining first step of CoA synthesis, we find that the minimally characterized but highly conserved PANK4 is a rate-limiting suppressor of CoA synthesis through its metabolite phosphatase activity.

Phosphorylation of PANK4 by AKT relieves this suppression. Ultimately, the PI3K–PANK4 axis regulates the abundance of acetyl-CoA and other acyl-CoAs, CoA-dependent processes such as lipid metabolism and proliferation. (R1)