Redox homeostasis, DNA damage and OCD

One more evidence that OCD and oxidative stress with DNA damage go together:

“The total and native thiol levels in patients with OCD were significantly lower, and the disulfide levels were significantly higher in patients with OCD than healthy control subjects. In addition, 8-OHdG, an indicator of DNA damage, was significantly lower in the control group compared to the patient group.

Conclusion: Increased levels of disulfide/native thiol and disulfide/total thiol in patients with OCD show that levels of oxidative stress were elevated and therefore, higher 8-OHdG levels in patients with OCD is a marker of oxidative DNA damage.” (R1)

Disulfide here is oxidised glutathione (GSSG), and native thiols include reduced GSH apparently.

This study found significant evidence of increased GSSG and of DNA damage in OCD patients.