TCN2 - Transcobalamin 2
Transcription factors
From the section “CHEA Transcription Factor Targets” (R1):
| Transcription factor | Notes |
|---|---|
| CEBPB | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. |
| CRX | CRX gene can directly regulate the expression of the TCN2 gene in cells of the retina. This suggests that CRX may play a role in maintaining the levels of vitamin B12 in the retina, which is important for the health and function of the cells that detect light. |
| KLF4 | |
| MECOM | |
| MITF | |
| NANOG | |
| NR0B1 | |
| PBX1 | |
| PPARD | |
| PPARG | |
| RELA | |
| RUNX1 | |
| SIN3B | |
| SREBF1 | |
| STAT5A | |
| TP53 |
CEBPB
Phosphorylated at Thr-235 by MAPK and CDK2, serves to prime phosphorylation at Thr-226 and Ser-231 by GSK3B and acquire DNA-binding as well as transactivation activities, required to induce adipogenesis.
MAPK and CDK2 act sequentially to maintain Thr-235 in the primed phosphorylated state during mitotical cloning expansion and thereby progression of terminal differentiation.
Phosphorylation at Thr-266 enhances transactivation activity. Phosphorylation at Ser-325 in response to calcium increases transactivation activity. Phosphorylated at Thr-235 by RPS6KA1