Thinking about fasting intolerance and RET

I’m chasing the cause of fat oxidation intolerance and currently found a few pieces of the puzzle that sound plausible. Perhaps somebody knows about the subject below?

1st piece: intolerance to melatonin. For some time I thought that some people don’t tolerate exogenous melatonin because it’s an Nrf2 inducer, or because it may inhibit thioredoxins, and is in general a pro-oxidant first, and antioxidant the second.

I found a study that shows how exactly melatonin exerts its anti-cancer effect - by inducing Reverse Electron Transport, which generates a lot of ROS, which kills the cancer cell.

2nd piece: Fat oxidation feeds complex 2, fixing vitamin B2 deficiency also increases activity of complex 2. Detoxification of H2S also happens at the complex 2.

3d piece: when electrons captured at complex 2 have no way to go when CQ10 pool is reduced too much, Reverse Electron Transport happens and drives the electrons from complex 2 to complex 1 (in reverse), generating a lot of ROS.

So my hypothesis is that in some people, dietary fat (or fasting) intolerance that causes increases oxidative stress may be happening because of RET, and the reason is low capacity of CQ10 pool.

If you have researched this topic (RET, ETC), can we discuss? :)