Hypoxia increases ROS production and activates Nrf2

Looks like this week goes under the flag of hypoxia.

“Human tissues experience hypoxia owing to various physiological ailments, including sepsis, sleep apnea, chronic obstructive pulmonary disease, diabetic kidney disease, and wound healing.

However, hypoxia has arguably been most well studied in the context of the solid tumor microenvironment, where it is associated with increased metastasis, resistance to anticancer chemotherapies, and poor patient prognosis.

A hallmark of hypoxia is the formation of radical oxygen species (ROS).”

Here we go. Cellular hypoxia increases oxidative stress.

Sleep apnea is mentioned as a cause of hypoxia.

Hypoxia also induces Nrf2. And as I wrote earlier, my hypothesis is that tics might be caused by chronic over-activation of Nrf2.