Nrf2 target genes

Antioxidant and detoxification network

Gene	Functional Description
GCLC	GCLC encodes the catalytic subunit of glutamate-cysteine ligase, the rate-limiting enzyme in glutathione synthesis	GCLC
GCLM	GCLM encodes the modifier subunit of glutamate-cysteine ligase	GCLM
GSR	glutathione reductase, an enzyme that maintains high levels of reduced glutathione in the cytosol	GSR
GSTM5	encodes glutathione S-transferase mu 5, involved in the detoxification of electrophilic compounds	GSTM5
GSTP1	encodes glutathione S-transferase pi 1, which is involved in the detoxification of carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress	GSTP1
TXN	TXN encodes thioredoxin, a protein involved in the regulation of cellular redox state and protection against oxidative stress.
TXNRD1	TXNRD1 encodes thioredoxin reductase 1, a protein involved in the regulation of cellular redox state and protection against oxidative stress.
PRDX1	Encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 protein breaks down hydrogen peroxide, controlling its levels in cells and protecting them from damage. It may also contribute to the antiviral activity of CD8(+) T-cells and play a role in cancer development or progression[3].	PRDX1
NQO1	NQO1 encodes NAD(P)H quinone dehydrogenase 1, an enzyme that protects cells from oxidative stress.	NQO1
NFE2L2	NFE2L2 encodes nuclear factor erythroid 2-related factor 2, a transcription factor that regulates the expression of antioxidant proteins.	NFE2L2

Pentose Phosphate Pathway

Gene	Functional Description
TKT	TKT encodes transketolase, a protein involved in the pentose phosphate pathway, which is essential for nucleic acid and energy metabolism.

Iron and heme metabolism

Gene	Functional Description
ABCB6	Involved in mitochondrial iron homeostasis and heme biosynthesis; functions as an ATP-binding cassette transporter.
FECH	Ferrochelatase, an enzyme that catalyzes the conversion of protoporphyrin IX to heme	FECH
FTH1	ferritin heavy chain 1, a protein that stores iron in a soluble, non-toxic, readily available form	FTH1
FTL	ferritin light chain, which also plays a role in iron storage	FTL
HMOX1	Encodes heme oxygenase 1, an enzyme that catalyzes the first step in the oxidative degradation of heme, with roles in antioxidant defense, iron homeostasis, and anti-inflammatory processes	HMOX1

Energy metabolism

Gene	Functional Description
ACO1	Functions as a cytosolic enzyme in the Krebs cycle, interconverting citrate to isocitrate.
ME1
GPI	GPI encodes glucose-6-phosphate isomerase, an enzyme that catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate. Glycolysis.	GPI

Lysosomal function

Gene	Functional Description
ABCB9	Functions as a lysosomal ATP-binding cassette transporter, likely involved in peptide transport.	Characterization of ABCB9, an ATP Binding Cassette Protein Associated with Lysosomes (R)

Proteasomal function

Gene	Functional Description
AMN1	Encodes a protein involved in regulating post-mitotic cell separation, highly conserved among different species[14].
HERC1	encodes HECT and RLD domain containing E3 ubiquitin protein ligase 1, which is involved in protein ubiquitination	HERC1
UBC	UBC encodes ubiquitin C, a protein involved in the regulation of cellular signaling pathways and protein degradation.
UBE2E2	UBE2E2 encodes ubiquitin-conjugating enzyme E2E2, a protein involved in the regulation of cellular signaling pathways and protein degradation.
VCP	VCP encodes valosin-containing protein, a protein involved in the regulation of cellular signaling pathways and protein degradation.	a member of the AAA(+) ATPase family of chaperone-like proteins that regulate numerous cellular processes, including chromatin organization, membrane fusion, ubiquitin-dependent protein degradation, and autophagy.
SQSTM1	SQSTM1 encodes sequestosome 1, a protein involved in the regulation of cellular signaling pathways and the degradation of target proteins.
RFFL	RFFL encodes ring finger protein, a protein involved in ubiquitination and proteasomal degradation of target proteins.
RNF213	RNF213 encodes ring finger protein 213, a member of the RING-type zinc finger family, which is involved in ubiquitination and proteasomal degradation of target proteins.
RNF220	RNF220 encodes ring finger protein 220, a member of the RING-type zinc finger family, which is involved in ubiquitination and proteasomal degradation of target proteins.
NPLOC4	NPLOC4 encodes NPL4 homolog, ubiquitin recognition factor, which is involved in the regulation of protein degradation.	NPLOC4

Transporters

Gene	Functional Description
SLC25A25	SLC25A25 encodes solute carrier family 25 member A25, a protein involved in the transport of mitochondrial carrier proteins.
SLC3A2	SLC3A2 encodes solute carrier family 3 member A2, a protein involved in the transport of amino acids and other solutes across cell membranes.
SLC48A1	SLC48A1 encodes solute carrier family 48 member A1, a protein involved in the transport of amino acids and other solutes across cell membranes.
SLC7A11	Cystine / Glutamate antiporter. Imports cystine into the cell in exchange for glutamic acid.
SLC9A7P1	SLC9A7P1 encodes solute carrier family 9 member A7 pseudogene 1, a non-functional gene that is a remnant of an ancestral gene.
SLCO5A1	SLCO5A1 encodes solute carrier organic anion transporter family member 5A1, a protein involved in the transport of organic anions across cell membranes.

Receptors

Gene	Functional Description
LRP8	Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands	LRP8

Transcription factors

Gene	Functional Description
RXRA	RXRA encodes retinoid X receptor alpha, a nuclear receptor that forms heterodimers with retinoic acid receptor.
PPARGC1B	PPARGC1B encodes peroxisome proliferator-activated receptor gamma coactivator 1-beta, a transcriptional coactivator that regulates genes involved in energy metabolism.	PPARGC1B
MAFG	Encodes the transcription factor MafG, a bZip Maf transcription factor protein that is one of the small Maf proteins. It forms a functional partner for p45 NF-E2 in activating globin gene expression	MAFG

Inflammation system

Gene	Functional Description
PTGES3	PTGES3 encodes prostaglandin E synthase 3, an enzyme involved in the synthesis of prostaglandin E2, which plays a role in inflammation and pain.

USORTED

Gene	Functional Description
ABCC5	Acts as a transporter protein that mediates cellular efflux of cyclic nucleotides and other substrates.
ACCN1	Also known as ASIC2, it is a member of the acid-sensing ion channel family contributing to sensation of pain and touch.
ACTR10	A component of the ARP2/3 complex involved in the regulation of actin cytoskeleton and cell motility.
ADAMTS12	An extracellular matrix-degrading enzyme that plays a role in tissue remodeling and potentially in inflammatory processes.
ADO	Catalyzes the deamination of adenosine, involved in purine metabolism and regulation of cellular signaling.
AFG3L1P	Presumed to be involved in the assembly, maintenance, or degradation of mitochondrial respiratory chain complexes.
AIFM2	Functions as an apoptosis-inducing factor with roles in redox reactions and possibly in iron metabolism.
AKIRIN2	A nuclear factor that plays a role in regulating gene expression during development and immune response.
ALOX12P2	A pseudogene related to arachidonate 12-lipoxygenase, not expressed in humans[15].
ALPI	Encodes intestinal alkaline phosphatase, a digestive brush-border enzyme involved in gut mucosal defense[16].
ANKRD11	Encodes a protein that interacts with other proteins to control gene activity, playing a role in neurons and brain development[4].
ANKRD30BL	.
ANO4	.
ARID3A
ARRDC3
ATXN1
ATXN3L
AZIN1
BCL2L11	Encodes Bcl-2-like protein 11 (BIM), a pro-apoptotic regulator that interacts with other members of the BCL-2 protein family. It plays a role in apoptosis, immune responses, and tumor progression[1].
BEND6	Acts as a nuclear antagonist of Notch signaling in neural stem cells, opposing their self-renewal and promoting neural commitment[2][7][15].
BMP10	Encodes bone morphogenetic protein 10, a protein involved in the trabeculation of the heart and known for its ability to induce bone and cartilage development[3][8][12].
BRD2	Encodes a novel protein kinase involved in cell cycle-responsive transcription[4].
C21orf33	Encodes a potential mitochondrial protein that is a member of the DJ-1/PfpI gene family. This protein is overexpressed in fetal Down syndrome[5][13].
C6orf106
C9orf25
C9orf5
CAMK2D
CAND1
CASC3
CCDC64
CD226
CD27
CD83
CDK17
CDK6
CEBPA
CHST11
CLIP4
CLLU1OS
CLTC	Encodes clathrin heavy chain, a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules	CLTC
CMPK1	Encodes an enzyme that catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. This enzyme plays a role in DNA repair	CMPK1
COL24A1	Encodes collagen type XXIV alpha 1 chain, a member of the collagen gene family. This protein is thought to regulate type I collagen fibrillogenesis during fetal development	COL24A1
CPEB2	Encodes cytoplasmic polyadenylation element binding protein 2, a RNA binding protein that regulates hormone sensing in mammary gland development and luminal breast cancer	CPEB2
CPEB3	Encodes cytoplasmic polyadenylation element binding protein 3, a RNA binding protein that functions as a tumor suppressor in colorectal cancer via JAK/STAT signaling. CPEB3 inhibits epithelial-mesenchymal transition	CPEB3
CREBZF		CREBZF
CWC27		CWC27
DAD1		DAD1
DCUN1D4		DCUN1D4
DENND4C		DENND4C
DGCR6L		DGCR6L
DNAJA2		DNAJA2
DST	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1	DST
DSTNP2		DSTNP2
DUSP2		DUSP2
DUSP5		DUSP5
EHMT1		EHMT1
EIF4G3		EIF4G3
ELN		ELN
EPB41		EPB41
ERC2		ERC2
EXOC7	Component of the exocyst complex involved in vesicular trafficking, critical for the targeting and fusion of vesicles to specific docking sites on the plasma membrane	EXOC7
FAM157A	Currently, there is limited information available on the function of this RNA gene	FAM157A
FAM76B	Nuclear speckle-localized protein that regulates the NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1, playing an anti-inflammatory role in macrophages	FAM76B
FASTKD2	Localized in the mitochondrial inner compartment and may play a role in mitochondrial apoptosis	FASTKD2
FLNB	filamin B, a protein that cross-links actin filaments and is involved in the remodeling of the cytoskeleton	FLNB
FSD1L	fibronectin type III and SPRY domain-containing protein 1-like, whose function is not well characterized	FSD1L
GABBR2	the GABA B receptor subtype 2, which is involved in neurotransmission in the central nervous system	GABBR2
GATS	GATS encodes GATA-binding protein 5, a transcription factor that may be involved in the regulation of gonad development	GATS
GCNT3	GCNT3 encodes glucosaminyl (N-acetyl) transferase 3, a member of the glycosyltransferase family involved in the biosynthesis of core 2 O-glycans	GCNT3
GDF15	growth differentiation factor 15, a member of the TGF-beta superfamily that has roles in regulating inflammation and cell cycle	GDF15
GPNMB	GPNMB encodes glycoprotein nmb, which is involved in cell differentiation, and may play a role in immune response, osteoclastogenesis, and tumorigenesis	GPNMB
GRM8	glutamate receptor metabotropic 8, involved in mediating excitatory neurotransmission	GRM8
HBB	encodes hemoglobin subunit beta, a component of hemoglobin that is involved in oxygen transport in the blood	HBB
HBE1	encodes hemoglobin subunit epsilon, a component of fetal hemoglobin	HBE1
HGD	homogentisate 1,2-dioxygenase, an enzyme involved in the catabolism of tyrosine	HGD
HIF1A	Encodes hypoxia-inducible factor 1-alpha, a transcription factor that plays a pivotal role in cellular response to oxygen levels and is involved in processes such as angiogenesis, metabolism, and cell survival	HIF1A
HIST1H4H	Encodes histone H4, which is responsible for the nucleosome structure of the chromosomal fiber in eukaryotes, playing a key role in the compaction of chromatin into higher order structures	HIST1H4H
HRASLS2	Also known as PLAAT2, this gene encodes a protein with phospholipase and acyltransferase activities and acts as a tumor suppressor	HRASLS2
HTATIP2		HTATIP2
HTRA3		HTRA3
IFRD1		IFRD1
IFT74		IFT74
IGF2R		IGF2R
IPO7		IPO7
IRF2		IRF2
IRF2BPL		IRF2BPL
KCNN3		KCNN3
KEAP1		KEAP1
KIAA1522		KIAA1522
KIFC3		KIFC3
LBR		LBR
LINC00273		LINC00273
LINC00299		LINC00299
LOC100130451		LOC100130451
LOC100132891		LOC100132891
LOC100507557		LOC100507557
LOC147646		LOC147646
LOC284661		LOC284661
LOC284801		LOC284801
LOC338758		LOC338758
LOC338799		LOC338799
LOC440461		LOC440461
LOC643723		LOC643723
LOC646329		LOC646329
LRRC8D	Encodes the leucine-rich repeat-containing protein 8D, which is involved in volume-sensitive anion channel activity, cellular response to osmotic stress, organic acid transport, and protein hexamerization	LRRC8D
LY9	Encodes the T-lymphocyte surface antigen Ly-9, a protein that belongs to the SLAM family of immunomodulatory receptors and interacts with the adaptor molecule SAP	LY9
MAPRE3	Encodes a plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton	MAPRE3
MAPT
MESDC1		[MESDC1]
MFSD11		[MFSD11]
MIAT		[MIAT]
MIR365A		[MIR365A]
MIR617		[MIR617]
MKLN1		[MKLN1]
MOV10L1		[MOV10L1]
MPPE1	Predicted to enable GPI anchor binding activity; involved in the transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi and acts in lipid remodeling steps of GPI-anchor maturation[1][8][11][14][17][20].	MPPE1
MSL3	A subunit of the MSL complex responsible for histone H4 lysine-16 acetylation of all cellular chromosomes; plays a role in chromatin remodeling and transcriptional regulation, and has a role in X inactivation[2][6][9][12][15][18].	MSL3
MTF2	Enables methylated histone binding activity and transcription corepressor binding activity; directly binds to DNA and is essential for recruitment of PRC2 both in vitro and in vivo[3][7][13][16][19].	MTF2
MYC	A super-transcription factor encoded by the MYC gene; regulates transcription of nearly 15% of expressed genes and is involved in cellular processes such as proliferation and apoptosis; deregulation can lead to various cancers	MYC
NES	NES encodes nestin, an intermediate filament protein expressed in stem cells during development.	NES
NEUROD4	NEUROD4 encodes neurogenic differentiation factor 4, a member of the NEUROD family of basic helix-loop-helix transcription factors.	NEUROD4
NKAIN1	NKAIN1 encodes sodium/potassium-transporting ATPase interacting 1, which may play a role in neuronal function.	NKAIN1
NUMBL	NUMBL encodes numb homolog (Drosophila)-like, a protein that plays a role in neurogenesis and the determination of cell fate.	NUMBL
NUP153	NUP153 encodes nucleoporin 153, a component of the nuclear pore complex involved in nucleocytoplasmic transport.	NUP153
OR2AT4	OR2AT4 encodes olfactory receptor family 2 subfamily AT member 4, a G-protein coupled receptor involved in the detection of odors.	OR2AT4
P2RY10	P2RY10 encodes a G-protein coupled receptor that may be involved in immune function.	P2RY10
PARN	PARN encodes poly(A)-specific ribonuclease, an enzyme involved in mRNA decay.	PARN
PDCD1LG2	PDCD1LG2 encodes programmed cell death 1 ligand 2, a protein that plays a role in the regulation of immune responses.	PDCD1LG2
PDCD6IP	PDCD6IP encodes programmed cell death 6 interacting protein, which is involved in endocytic trafficking and apoptosis.	PDCD6IP
PEX5L	PEX5L encodes peroxisomal biogenesis factor 5-like, involved in the import of peroxisomal matrix proteins.	PEX5L
PGRMC2	PGRMC2 encodes progesterone receptor membrane component 2, which may be involved in steroid signaling.	PGRMC2
PIP5K1C	PIP5K1C encodes phosphatidylinositol-4-phosphate 5-kinase type 1 gamma, an enzyme involved in the synthesis of phosphatidylinositol 4,5-bisphosphate.	PIP5K1C
PIR	PIR encodes pirin, a protein that may play a role in nuclear functions such as transcription and DNA repair.	PIR
PLA2G6	PLA2G6 encodes phospholipase A2 group VI, an enzyme involved in the release of fatty acids from phospholipids.	PLA2G6
PMAIP1	PMAIP1 encodes phorbol-12-myristate-13-acetate-induced protein 1, a pro-apoptotic member of the Bcl-2 protein family.	PMAIP1
PMF1	PMF1 encodes polyamine-modulated factor 1, which may be involved in the regulation of RNA processing or translation.	PMF1
PPIF	Encodes an enzyme that is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. This protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. PPIF is a major component of the mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases and related conditions, including cardiac diseases, neurodegenerative diseases, and muscular dystrophy[1].
PRDM1	Encodes a protein that acts as a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid cell differentiation. PRDM1 also acts as a tumor-suppressor gene in certain types of cancers[2].	PRDM1
PRKACB	Encodes a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of the cAMP-dependent protein kinase, which is involved in the regulation of cellular responses to hormonal signals[4].	PRKACB
PRKCB	Encodes a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of the cAMP-dependent protein kinase, which is involved in the regulation of cellular responses to hormonal signals[4].	PRKCB
PSMA3	Encodes a protein that is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. This protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins[5].	PSMA3
PVRL1	PVRL1 encodes nectin-like 5, a cell adhesion molecule involved in cell-cell adhesion and signaling.	[PVRL1
PVT1	PVT1 encodes plasmacytoma variant translocation 1, a gene that is involved in the regulation of cell growth and differentiation.	[PVT1
RAB10	RAB10 encodes RAB10, a member of the RAS superfamily of GTPases, which are involved in the regulation of cellular signaling pathways.	[RAB10
RAB35	RAB35 encodes RAB35, a member of the RAS superfamily of GTPases, which are involved in the regulation of cellular signaling pathways.	[RAB35
RASAL3	RASAL3 encodes RASAL3, a member of the RAS superfamily of GTPases, which are involved in the regulation of cellular signaling pathways.	[RASAL3
RASSF6	RASSF6 encodes RAS-association domain family 6, a member of the RAS superfamily of GTPases, which are involved in the regulation of cellular signaling pathways.	[RASSF6
RCAN1	Encodes regulator of calcineurin 1, a protein that regulates calcineurin, a calcium-dependent phosphatase involved in various cellular processes, including immune response and neuronal function[1].
ROCK1	ROCK1 encodes Rho-associated coiled-coil containing protein kinase 1, a serine/threonine kinase involved in the regulation of cell shape, migration, and division.
RSPH6A	RSPH6A encodes radial spoke head 6 homolog A (S. cerevisiae), a protein involved in ciliary and flagellar motility.
SAR1B	SAR1B encodes Sec1/Munc18-like 1B, a protein involved in vesicle trafficking and fusion, playing a role in the regulation of membrane transport and cellular communication.
SEC61B	SEC61B encodes SEC61 homolog B (S. cerevisiae), a protein involved in vesicle trafficking and fusion, playing a role in the regulation of membrane transport and cellular communication.
SEMA7A	Encodes a semaphorin, which is involved in the regulation of cell-cell communication and signaling, playing a role in various biological processes, including immune response and neuronal function[1].
SETBP1	SETBP1 encodes SET binding protein 1, a protein involved in the regulation of gene expression and chromatin remodeling.
SH2D6	SH2D6 encodes SH2 domain-containing protein 6, a protein involved in signal transduction and cellular signaling pathways.
SLAMF7	SLAMF7 encodes signaling lymphocytic activation molecule family member 7, a cell surface receptor involved in the regulation of immune response and cell-cell communication.
SORBS2	SORBS2 encodes sorbin and SH3 domain-containing protein 2, a protein involved in the regulation of cellular signaling pathways and membrane trafficking.
SPRY3	SPRY3 encodes sprouty homolog 3, a protein involved in the regulation of cell growth and differentiation.
SRXN1	Encodes sulfiredoxin 1, a protein that enables oxidoreductase activity on sulfur groups of donors and is involved in the response to oxidative stress[1].
SSH1	SSH1 encodes Slingshot homolog 1, a protein involved in the regulation of cell cycle and cytoskeletal organization.
ST6GALNAC1	ST6GALNAC1 encodes ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, a protein involved in the synthesis of sialylated glycans.
STARD13	STARD13 encodes StAR-related lipid transfer domain-containing protein 13, a protein involved in the transport and metabolism of lipids.
STXBP4	STXBP4 encodes syntaxin-binding protein 4, a protein involved in the regulation of membrane trafficking and neurotransmitter release.
SUMO1P1	SUMO1P1 encodes SUMO1 pseudogene 1, a non-functional gene that is a remnant of an ancestral gene.
TANK	TANK encodes TRAF family member-associated NF-kappaB activator, a protein involved in the regulation of NF-kappaB signaling and immune response.
TBL1X	TBL1X encodes transducin beta-like 1X-linked, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
TBXAS1	TBXAS1 encodes T-box and ASH-like 1, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
TCL6	TCL6 encodes T-cell leukemia/lymphoma 6, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
TEC	TEC encodes tyrosine kinase expressed in hepatocellular carcinoma, a protein involved in the regulation of cellular signaling pathways and cell growth.
TFE3	TFE3 encodes transcription factor E3, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
THBS1	THBS1 encodes thrombospondin 1, a protein involved in the regulation of cell adhesion, migration, and angiogenesis.
TMEM121	TMEM121 encodes transmembrane protein 121, a protein involved in the regulation of cellular signaling pathways and membrane trafficking.
TMTC3	TMTC3 encodes transmembrane protein 3, a protein involved in the regulation of cellular signaling pathways and membrane trafficking.
TNFRSF1A	TNFRSF1A encodes tumor necrosis factor receptor superfamily member 1A, a protein involved in the regulation of cellular signaling pathways and immune response.
TNFRSF8	TNFRSF8 encodes tumor necrosis factor receptor superfamily member 8, a protein involved in the regulation of cellular signaling pathways and immune response.
TNFSF14	TNFSF14 encodes tumor necrosis factor superfamily member 14, a protein involved in the regulation of cellular signaling pathways and immune response.
TRIM56	TRIM56 encodes tripartite motif-containing protein 56, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
TSC22D1	TSC22D1 encodes TSC complex subunit 22 homolog D1, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
UNKL	UNKL encodes unknown, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
VEZF1	VEZF1 encodes vestigial-like 1, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
VTRNA1-1	VTRNA1-1 encodes small nuclear RNA 1-1, a non-coding RNA involved in the regulation of gene expression and splicing.
WDR81	WDR81 encodes WD repeat-containing protein 81, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
WIPI2	WIPI2 encodes WD repeat-containing protein interacting with phosphoinositides 2, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
YWHAG	YWHAG encodes tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, which is involved in the regulation of cellular signaling pathways and protein degradation.
ZFAT	ZFAT encodes zinc finger protein A20, a protein involved in the regulation of cellular signaling pathways and transcriptional control. A20 has been found to play a role in various cellular processes, including immune response, inflammation, and apoptosis[4].
ZMYND8	ZMYND8 encodes zinc finger MYND-type containing 8, a protein that has been found to sensitize intestinal tumors to the inhibition of the mevalonate pathway[1]. It also plays a role in breast and prostate cancer, acting as a tumor suppressor and inhibiting tumor growth by promoting differentiation[3].
ZNF148	ZNF148 encodes zinc finger protein 148, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZNF3	ZNF3 encodes zinc finger protein 3, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZNF469	ZNF469 encodes zinc finger protein 469, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZNF673	ZNF673 encodes zinc finger protein 673, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZFAT	ZFAT encodes zinc finger protein A20, a protein involved in the regulation of cellular signaling pathways and transcriptional control. A20 has been found to play a role in various cellular processes, including immune response, inflammation, and apoptosis[4].
ZMYND8	ZMYND8 encodes zinc finger MYND-type containing 8, a protein that has been found to sensitize intestinal tumors to the inhibition of the mevalonate pathway[1]. It also plays a role in breast and prostate cancer, acting as a tumor suppressor and inhibiting tumor growth by promoting differentiation[3].
ZNF148	ZNF148 encodes zinc finger protein 148, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZNF3	ZNF3 encodes zinc finger protein 3, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZNF469	ZNF469 encodes zinc finger protein 469, a protein involved in the regulation of cellular signaling pathways and transcriptional control.
ZNF673	ZNF673 encodes zinc finger protein 673, a protein involved in the regulation of cellular signaling pathways and transcriptional control.