Uranium inhibits Nrf2 activity

Deleterious effects of Uranium exposure:

Uranium contamination decreased Nrf2 protein expression and nuclear translocation.

RNA silencing of Nrf2 gene expression in kidney cells which had not been treated by uranium decreased CBS and CSE gene expression and endogenous H2S generation, which mirrored the effects of uranium exposure. (R1)

That is, Uranium makes it hard to detox Uranium by lowering Nrf2 activation, which means, it gets stuck there unless Nrf2 is activated “manually” (by eating foods / supplements that contain Nrf2 activators).