Cannabidiol induces antioxidant pathways

Ah, turns out CBD also induces downstream genes of Nrf2 that are related to antioxidant defense system.

No wonder it helps to reduce anxiety (in case if that is caused by high oxidative stress) and tics (the same reasons).

And this also means, that in case of insufficient selenium or in presence of Mercury, CBD, like any other Nrf2 activator, have a good chance to produce negative symptoms because the enzyme TXNRD, which is supposed to be helping, will amplify oxidative stress instead of reducing it - because this is what it does when there not enough selenium or even mild mercury poisoning.

In addition, CBD induced the expression of several NRF2 target genes, with heme oxygenase 1 (HMOX1) being the gene and the protein most upregulated by CBD.

CRISPR/Cas9-mediated genome editing, RNA interference and biochemical studies demonstrated that the induction of HMOX1 mediated by CBD, involved nuclear export and proteasomal degradation of the transcriptional repressor BACH1.

Notably, we showed that the effect of BACH1 on HMOX1 expression in keratinocytes is independent of NRF2. (R1)