Retinoic acid inhibits Nrf2

In the article (R1), they briefly mentioned Retinoic acid (vitamin A, by the way) as an inhibitor of Nrf2!

That alarmed me, because our kid reacted with severe OCD crisis to both Vitamin A and beta-carotenes - I thought it’s because beta-carotenes are mitochondrial toxin, but this next study identifies Retinoic Acid as Nrf2 inhibitor - no wonder high doses of Vitamin A are used like a chemotherapy to treat Psoriasis and patients report significant mood issues (depression, low energy) -the treatment is killing “mad” cells by high oxidative stress, while also damaging the rest of the body.

Second paper reports:

Using a human mammary MCF7-derived AREc32 reporter cell line, we now report that all-trans retinoic acid (ATRA), and other retinoic acid receptor alpha (RARalpha) agonists markedly reduces the ability of Nrf2 to mediate induction of ARE-driven genes by cancer chemopreventive agents including the metabolite of butylated hydroxyanisole, tert-butylhydroquinone (tBHQ). (R2)