Metabolic Dangers of Nrf2 activation
Nrf2 KEAP1 NAD ALDH3A1 Reductive Stress
L-selenocystine is toxic for Nrf2 addicted cells
Nrf2 Selenocystine Autophagy p62 KEAP1 Oxidative Stress AKT mTOR ULK1 Beclin1
Higher Nrf2 activation may be needed for activating metabolic genes vs. cytoprotective genes
Nrf2 PI3K Akt PTEN KEAP1
Nrf2 activation leads to imbalance of carbon metabolism
NRF2 Glutamine Glutamate GSH KEAP1 xCT
O‐GlcNAcylation
O‐GlcNAcylation Glycosylation OGT OGA KEAP1 NRF2 NRF1
Amoxicillin decreased KEAP1, CPT1, CHOP expression and PPARa transactivation
Amoxicillin NRF2 KEAP1 CPT1 CHOP PPARa Carnitine Tics
Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury
Nrf2 Cadmium KEAP1 autophagy
Alternative explanation how Nrf2 activation works
Nrf2 KEAP1
Inactivation of TrxR1 leads to Nrf2 activation
TXNRD1 Selenium Nrf2 KEAP1