Metabolic Dangers of Nrf2 activation
Nrf2 KEAP1 NAD ALDH3A1 Reductive Stress
SIRT5 restores activity of GCDH
GCDH 3-hydroxyglutaric Glutaric NAD SIRT5 glutarylation PTM
NAD
NAD
Endogenous ROS
NAD Lipoic acid GSH
Reverse Electron Transport
RET ETC Oxidative stress NAD
NAD supresses Akt activation via SIRT7-FKBP51-PHLPP
AKT SIRT7 NAD PHLPP FKBP51 GSK3b
Fat processing depends on PGC-1a
PGC1a Fasting Fat oxidation NAD Methylation potential
Serine
Serine Heme Glutamate NAD SHMT
Role of thiamine in NAD+ synthesis from Niacin and Nicotinamide
Thiamine NAD Niacin Nicotinamide Ribose PRPP
Retinoic acid and NAD
NAD Retinoic acid
Nrf2 activation depends on NAD status
Nrf2 NAD BACH1 SIRT6