Deregulated Nrf2-Keap1-BACH1 axis in autism spectrum disorder
NRF2 BACH1 Autism ASD Tics p62 Heme Iron
Apple's content activate Nrf2
Apple Nrf2
Metabolic Dangers of Nrf2 activation
Nrf2 KEAP1 NAD ALDH3A1 Reductive Stress
L-selenocystine is toxic for Nrf2 addicted cells
Nrf2 Selenocystine Autophagy p62 KEAP1 Oxidative Stress AKT mTOR ULK1 Beclin1
Activation of WNT3A prevents deactivation of Nrf2 by GSK3b
WNT3A Nrf2 GKS3b Axin1
MAPK, p62, autophagy and inflammation
MAPK SQSTM1 p62 Autophagy GABA-A Receptor ULK1 Inflammation NRF2
Higher Nrf2 activation may be needed for activating metabolic genes vs. cytoprotective genes
Nrf2 PI3K Akt PTEN KEAP1
Nrf2 activation leads to imbalance of carbon metabolism
NRF2 Glutamine Glutamate GSH KEAP1 xCT
O‐GlcNAcylation
O‐GlcNAcylation Glycosylation OGT OGA KEAP1 NRF2 NRF1
Oxidative stress lowers testosterone production
SIRT1 NRF2 Testosterone Progesterone NAM Niacinamide Oxidative stress Hypogonadism Luteinizing hormone
Amoxicillin decreased KEAP1, CPT1, CHOP expression and PPARa transactivation
Amoxicillin NRF2 KEAP1 CPT1 CHOP PPARa Carnitine Tics
Progesterone inhibits GSK3b
Progesterone GSK3b Nrf2 Akt Chromium Vanadium Menstrual Cycle
Genetic overactivation of Nrf2: consequences and treatment
Nrf2 NFE2L2 Luteolin Ascorbic acid Immunodeficiency Hyperkeratosis Hypohomocysteinaemia G6PD
Nrf2 target genes
Nrf2
Role of MAFF in dampening Nrf2 signal
Nrf2 MAFF Hypoxia HIF1 IL1b TNFa Cytokines
Inhibited autophagy blocks xCT transport to the membrane
Autophagy Nrf2 xCT SLC7A11 Cystine
Boron
Boron Nrf2
Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury
Nrf2 Cadmium KEAP1 autophagy
Elevated ethylmalonic acid can be a result of Nrf2 activation
Nrf2 Cystine Persulfides xCT SLC7A11 SQOR
Excessive cysteine, H2S and PPI
PPI H2S Cysteine ETC RET Nrf2
Zinc
Zinc Nrf2 Akt GSK3b
Akt is the first responder. Essential role of Vanadium
Akt Nrf2 Vanadium Chromium
Signalling cascades
Nrf2 PI3K GSK3b Akt WNT Beta-catenin AMPK
Myrrh essential oil is an nrf2 activator
Essential oil Myrrh Nrf2 HO-1 Oxidative stress
GSK3b the pacifier
GSK3b HIF1 NRF2
Hypoxia increases ROS production and activates Nrf2
Hypoxia Nrf2 Apnea Oxidative stress
Hypoxia and GSK3b
hypoxia GSK3b HIF-1 OCD Nrf2
PGC-1a
PGC1a Nrf1 Nrf2 Fat oxidation Fasting Resveratrol Methionine cycle Mitochondria Schizophrenia CQ10 RXR Retinoic acid
AMPK
AMPK Iron deficiency Nrf2 Chromium
Nrf2
Nrf2 Oxidative stress
Nrf2 activation depends on NAD status
Nrf2 NAD BACH1 SIRT6
Cannabidiol induces antioxidant pathways
CBD ECS NRF2 Oxidative stress BACH1
Uranium inhibits Nrf2 activity
Uranium Nrf2 CSE CBS H2S
Nrf2's ability to activate is dependent on methylation
Nrf2 Methylation potential
Binding of Nrf2 to DNA is increased by methylation
Methylation PRMT1 Nrf2
Overactivation of Nrf2 induced tics
Nrf2 Tics
Overactivation of Heme Oxigenase 1 early in life leads to symptoms similar to schizophrenia or Parkinson's disease
Schizophrenia HMOX1 HO1 Nrf2 Oxidative stress PPI Hyperkinesia olfaction
Alternative explanation how Nrf2 activation works
Nrf2 KEAP1
Inactivation of TrxR1 leads to Nrf2 activation
TXNRD1 Selenium Nrf2 KEAP1
Mercury inhibits Nrf2 activity
Mercury Nrf2 Selenium
Chronic oxidative stress impairs Nrf2 activation
Nrf2 Oxidative stress
Retinoic acid inhibits Nrf2
Retinoic acid Nrf2
Chromium
Chromium NRF2 Oxidative Stress AMPK Akt GLUT4 eNOS ACC TNF-alpha IL-6 CRP ER stress
Addressing Glutathione Depletion
Glutathione Nrf2 Sulforaphane MSM Resveratrol Ascorbic acid