Deregulated Nrf2-Keap1-BACH1 axis in autism spectrum disorder
NRF2 BACH1 Autism ASD Tics p62 Heme Iron
L-selenocystine is toxic for Nrf2 addicted cells
Nrf2 Selenocystine Autophagy p62 KEAP1 Oxidative Stress AKT mTOR ULK1 Beclin1
MAPK, p62, autophagy and inflammation
MAPK SQSTM1 p62 Autophagy GABA-A Receptor ULK1 Inflammation NRF2
Palmitoylation of Gephyrin
Gephyrin Palmitoylation ZDHHC12 Claudin-3 NLRP3 ZDHHC13 ZDHHC19 SQSTM1 p62 ZDHHC21
Role of excessive ubiquitination in BH4 deficiency
BH4 Tetrahydrobiopterin GTPCH1 Ubiquitination p62 Hypertension Diabetes Mellitus 2 Autophagy Lysosome
Reduced autophagy leads to reduction of GABA-A receptors
Autophagy GABA-A p62 SQSTM1