Interactions of Coenzyme Q10 and PI3K-Akt pathway
CQ10 Akt PI3K Autophagy mTOR
Higher Nrf2 activation may be needed for activating metabolic genes vs. cytoprotective genes
Nrf2 PI3K Akt PTEN KEAP1
PI3K/Akt regulates CoA synthesis
Coenzyme A PI3K AKT PANK2 PANK4 Chromium Vanadium
Fear extinction
AKT PI3K Fear extinction MAPK Calcineurin PKA CaMK2 CB1 PP1
Energy deprivation inhibits Akt
Akt AMPK Energy PI3K IRS-1
Role of Vanadium in Akt signalling
Vanadium Akt GSK3b Chromium Inositol PI3K SCD Oxidative stress PTP1B PHLPP FAS PEPCK PTEN
Signalling cascades
Nrf2 PI3K GSK3b Akt WNT Beta-catenin AMPK