Nrf2 activation leads to imbalance of carbon metabolism
NRF2 Glutamine Glutamate GSH KEAP1 xCT
Inhibited autophagy blocks xCT transport to the membrane
Autophagy Nrf2 xCT SLC7A11 Cystine
Elevated ethylmalonic acid can be a result of Nrf2 activation
Nrf2 Cystine Persulfides xCT SLC7A11 SQOR