My Posts

Klazomania - compulsive, paroxysmal, loud shouting
Beta-Mannosidase Deficiency and TS
Tourette Syndrome Beta-mannosidase deficiency MANBA Lysosome Mental retardation Hearing loos Behavior Infections Mannose N-acetylglucosamine NAG
Macrocytosis (folate/B12 deficiencies) and microcytosis (iron deficiency)
Macrocytosis Microcytosis MCV MCH Folate B12
Activation of the inflammasome NLRP3 by oxidative stress
Inflammasome NLRP3 Oxidative stress GSH H2S
BTBD9 gene and TS
BTBD9 CRL3 Tourette syndrome Iron Autophagy MEIS1 MAP2K5 SKOR1 RLS IRP2
Traumatic Brain Injury impairs degradation of autophagosomes
TBI Autophagy
Pimozide promotes autophagy, used to lower tics
Pimozide Autophagy UPR Tourette syndrome Schizophrenia Psychosis
Reduced autophagy leads to reduction of GABA-A receptors
Autophagy GABA-A p62 SQSTM1
Inhibited autophagy blocks xCT transport to the membrane
Autophagy Nrf2 xCT SLC7A11 Cystine
Biotin deficiency and high cholesterol
biotin cholesterol
Role of Allopregnanolone in tics severity
Allopregnanolone Tics Tourette syndrome GABA Interneurons
Role of GSK3b in fear memory
GSK3b Memory
GSK3b induces autophagy
GSK3b Autophagy mTORC1 ULK1
ASD panel from Igenomix
Genetics Autism Igenomix
ARHGEF9 and startle disease
ARHGEF9 GSK3b GABA receptors Glycine receptors Gephyrin
Nitric Oxide inhibits Methionine Synthase
Nitric Oxide Methionine Synthase Methionine Serine Homocysteine NAME
SIRT5 restores activity of GCDH
GCDH 3-hydroxyglutaric Glutaric NAD SIRT5 glutarylation PTM
Inhibition of FECH and Photosensitivity
Photosensitivity FECH Ferrochelatase Heme
Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury
Nrf2 Cadmium KEAP1 autophagy
NADPH made by NNT in mito from NADH supplied by aKGDH
NNT NADH NADPH aKGDH
Radical SAMe enzyme LIAS and Lipoic acid
Lipoic acid Lipoate LIAS Radical SAMe
RSAD1 is a heme chaperone catalyzing the insertion of heme into hemoproteins
heme iron SAMe RSAD1
Hypoxic Impairment of a Brainstem Locus in Autism
SAMe deficiency impairs assembly of OXPHOS
SAMe Mitochondria Complex I Methylation Iron-Sulfur clusters
Elevated ethylmalonic acid can be a result of Nrf2 activation
Nrf2 Cystine Persulfides xCT SLC7A11 SQOR
B12 deficiency as a source of Acrylic acid in OAT
Acrylic acid
SOD1 is an essential H2S detoxifying enzyme
H2S SOD1
Coenzyme Q10 upregulates SQOR and downregulates CBS, CSE
Transsulfuration CBS CSE SQOR CQ10
Chromium inhibits ATP synthase directly
Chromium Mitochondria
Supercomplexes in ETC
ETC Respirosome RET GPD2 CHDH ETFDH SQOR PRODH DHODH
hCTR1 has the capacity to reduce Cu(II)
Copper
Arsenic detox by AS3MT
Arsenic Methylation GSH
Excessive cysteine, H2S and PPI
PPI H2S Cysteine ETC RET Nrf2
Thinking about fasting intolerance and RET
FAO RET Melatonin
GSK3b inhibits CBS
Toxic dopamine inside the cells
Dopamine DJ-1 Oxidative stress
Motor-like Tics are Mediated by Cannabinoid Receptor 2-dependent Mechanism
ECS CB2 Tics Endocannabinoids
Oxidative stress in Tourette's syndrome
Probiotics modulate Akt differently
Akt Probiotics L. reuteri B. Breve S. cerevisiae L. rhamnosus L. acidophilus
Akt is the first responder. Essential role of Vanadium
Akt Nrf2 Vanadium Chromium
Risperidone and Olanzapine induce ER stress
Risperidone Olanzapine ER Stress Obesity Hypermetaoblism Antipshycotics
Vanadate inhibits PTP1B
Vanadium PTP1B Obesity Insulin Leptin Anxiety Inflammation
Role of Vanadium in Akt signalling
Vanadium Akt GSK3b Chromium Inositol PI3K SCD Oxidative stress PTP1B PHLPP FAS PEPCK PTEN
Genes Can Move From the Maternal to Infant Microbiome
Myristic acid and Akt protein
AKT Myristic acid
NAD supresses Akt activation via SIRT7-FKBP51-PHLPP
AKT SIRT7 NAD PHLPP FKBP51 GSK3b
Why fever can improve symptoms in some kids
Akt Fever GSK3b
GSK3b regulates Gephyrin
GSK3b Gephyrin GABA Lithium
Ketamine is a GSK3b inhibitor
GSK3b Ketamine OCD Depression AMPA
Myrrh essential oil is an nrf2 activator
Essential oil Myrrh Nrf2 HO-1 Oxidative stress