My Posts

Activation of the inflammasome NLRP3 by oxidative stress
July 31, 2023
#Inflammasome #NLRP3 #Oxidative stress #GSH #H2S
BTBD9 gene and TS
July 24, 2023
#BTBD9 #CRL3 #Tourette syndrome #Iron #Autophagy #MEIS1 #MAP2K5 #SKOR1 #RLS #IRP2
Traumatic Brain Injury impairs degradation of autophagosomes
July 21, 2023
#TBI #Autophagy
Pimozide promotes autophagy, used to lower tics
July 20, 2023
#Pimozide #Autophagy #UPR #Tourette syndrome #Schizophrenia #Psychosis
Reduced autophagy leads to reduction of GABA-A receptors
July 18, 2023
#Autophagy #GABA-A #p62 #SQSTM1
Inhibited autophagy blocks xCT transport to the membrane
July 18, 2023
#Autophagy #Nrf2 #xCT #SLC7A11 #Cystine
Biotin deficiency and high cholesterol
July 8, 2023
#biotin #cholesterol
Role of Allopregnanolone in tics severity
July 5, 2023
#Allopregnanolone #Tics #Tourette syndrome #GABA #Interneurons
Role of GSK3b in fear memory
June 29, 2023
#GSK3b #Memory
GSK3b induces autophagy
June 28, 2023
#GSK3b #Autophagy #mTORC1 #ULK1
ASD panel from Igenomix
June 15, 2023
#Genetics #Autism #Igenomix
ARHGEF9 and startle disease
June 14, 2023
#ARHGEF9 #GSK3b #GABA receptors #Glycine receptors #Gephyrin
Nitric Oxide inhibits Methionine Synthase
June 8, 2023
#Nitric Oxide #Methionine Synthase #Methionine #Serine #Homocysteine #NAME
SIRT5 restores activity of GCDH
May 29, 2023
#GCDH #3-hydroxyglutaric #Glutaric #NAD #SIRT5 #glutarylation #PTM
Inhibition of FECH and Photosensitivity
May 25, 2023
#Photosensitivity #FECH #Ferrochelatase #Heme
Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury
May 23, 2023
#Nrf2 #Cadmium #KEAP1 #autophagy
NADPH made by NNT in mito from NADH supplied by aKGDH
May 16, 2023
#NNT #NADH #NADPH #aKGDH
Radical SAMe enzyme LIAS and Lipoic acid
May 15, 2023
#Lipoic acid #Lipoate #LIAS #Radical SAMe
RSAD1 is a heme chaperone catalyzing the insertion of heme into hemoproteins
May 14, 2023
#heme #iron #SAMe #RSAD1
Hypoxic Impairment of a Brainstem Locus in Autism
May 9, 2023
SAMe deficiency impairs assembly of OXPHOS
May 9, 2023
#SAMe #Mitochondria #Complex I #Methylation #Iron-Sulfur clusters
Elevated ethylmalonic acid can be a result of Nrf2 activation
May 3, 2023
#Nrf2 #Cystine #Persulfides #xCT #SLC7A11 #SQOR
B12 deficiency as a source of Acrylic acid in OAT
April 22, 2023
#Acrylic acid
SOD1 is an essential H2S detoxifying enzyme
April 18, 2023
#H2S #SOD1
Coenzyme Q10 upregulates SQOR and downregulates CBS, CSE
April 16, 2023
#Transsulfuration #CBS #CSE #SQOR #CQ10
Chromium inhibits ATP synthase directly
April 12, 2023
#Chromium #Mitochondria
Supercomplexes in ETC
April 10, 2023
#ETC #Respirosome #RET #GPD2 #CHDH #ETFDH #SQOR #PRODH #DHODH
hCTR1 has the capacity to reduce Cu(II)
April 7, 2023
#Copper
Arsenic detox by AS3MT
April 1, 2023
#Arsenic #Methylation #GSH
Excessive cysteine, H2S and PPI
March 31, 2023
#PPI #H2S #Cysteine #ETC #RET #Nrf2
Thinking about fasting intolerance and RET
March 28, 2023
#FAO #RET #Melatonin
GSK3b inhibits CBS
March 24, 2023
Toxic dopamine inside the cells
March 20, 2023
#Dopamine #DJ-1 #Oxidative stress
Motor-like Tics are Mediated by Cannabinoid Receptor 2-dependent Mechanism
March 12, 2023
#ECS #CB2 #Tics #Endocannabinoids
Oxidative stress in Tourette's syndrome
March 12, 2023
Probiotics modulate Akt differently
March 2, 2023
#Akt #Probiotics #L. reuteri #B. Breve #S. cerevisiae #L. rhamnosus #L. acidophilus
Akt is the first responder. Essential role of Vanadium
March 2, 2023
#Akt #Nrf2 #Vanadium #Chromium
Risperidone and Olanzapine induce ER stress
March 2, 2023
#Risperidone #Olanzapine #ER Stress #Obesity #Hypermetaoblism #Antipshycotics
Vanadate inhibits PTP1B
March 1, 2023
#Vanadium #PTP1B #Obesity #Insulin #Leptin #Anxiety #Inflammation
Role of Vanadium in Akt signalling
February 27, 2023
#Vanadium #Akt #GSK3b #Chromium #Inositol #PI3K #SCD #Oxidative stress #PTP1B #PHLPP #FAS #PEPCK #PTEN
Genes Can Move From the Maternal to Infant Microbiome
February 26, 2023
Myristic acid and Akt protein
February 25, 2023
#AKT #Myristic acid
NAD supresses Akt activation via SIRT7-FKBP51-PHLPP
February 25, 2023
#AKT #SIRT7 #NAD #PHLPP #FKBP51 #GSK3b
Why fever can improve symptoms in some kids
February 22, 2023
#Akt #Fever #GSK3b
GSK3b regulates Gephyrin
February 20, 2023
#GSK3b #Gephyrin #GABA #Lithium
Ketamine is a GSK3b inhibitor
February 20, 2023
#GSK3b #Ketamine #OCD #Depression #AMPA
Myrrh essential oil is an nrf2 activator
February 18, 2023
#Essential oil #Myrrh #Nrf2 #HO-1 #Oxidative stress
GSK3b explained
February 17, 2023
#GSK3b #BDNF #Depression #Anxiety #UPR #REDD1 #mTOR #CHOP #IGF-1 #EGF #WNT #PKA #CaMK2 #PP2A #PP2B
Suspected role of Chromium in disinhibition
February 16, 2023
#Disinhibition #Binge Eating Disorder #Chromium
Dopamine signalling inhibits Akt, leading to activation of GSK3b
February 16, 2023
#Dopamine #GSK3b #Akt #Lithium